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Through another transcription factor by the name of p53: p53 is a homo-tetrameric transcription factor composed of an N-terminal trans-activation domain (TAD, residues 161), a prolin-rich domain (PR, residues 6492), a central DNA-binding domain (DBD, residues 93293) followed by a tetramerization domain (TD, residues 325355) and the C-terminal negative regulatory domain (NRD, residues 367393) (Fig

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This ensures a pharmacist is able to review a patients comorbidities and medications before they are obtained

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Interestingly, if HIF-1 is inhibited, hypoxic cancer cells engage compensatory pathways (Myc, PI3K-Akt, AMPK) to sustain glycolysis and fructose utilization (27)